Deadliest disease outbreaks

As of 2026-10-12, Swine fever outbreak in Belgium in 1990 tops the list with 1,200,000 deaths.

1. #1 Swine fever outbreak in Belgium in 1990 — 1,200,000 deaths source Wikidata
2. #2 1889–1890 pandemic — 1,000,000 deaths

   worldwide pandemic beginning in 1889

   source Wikidata
3. #3 Italian Plague of 1629-1631 — 1,000,000 deaths

   series of outbreaks of bubonic plague in northern and central Italy

   source Wikidata
4. #4 Swine fever outbreak in Belgium — 790,000 deaths source Wikidata
5. #5 2009 swine flu pandemic — 284,000 deaths

   2009–2010 pandemic of swine influenza caused by H1N1 influenza virus

   source Wikidata
6. #6 Great Plague of London — 75,000 deaths

   pandemic lasting from 1665 to 1666, last major epidemic of the bubonic plague to occur in England

   source Wikidata
7. #7 Spanish flu of 1918-1919 in Sweden — 38,453 deaths

   disease outbreak in Sweden

   source Wikidata
8. #8 Spanish flu of 1918-1919 in Switzerland — 24,500 deaths source Wikidata
9. #9 Cholera outbreak in the Netherlands in 1866 — 21,000 deaths source Wikidata
10. #10 Spanish flu in Austria — 21,000 deaths source Wikidata